Schwitter J, Debatin J F, von Schulthess G K, McKinnon G C
Department of Radiology, University Hospital, Zurich, Switzerland.
Magn Reson Med. 1997 Jan;37(1):140-7. doi: 10.1002/mrm.1910370120.
A new magnetic resonance imaging strategy is presented for accessing myocardial perfusion. Most previous work has relied on using T1-weighted fast gradient-echo imaging to monitor dynamically the signal changes during the passage of a contrast media bolus. However, the gradient-echo approach is limited by an inability to image the entire heart with adequate temporal resolution. This paper focuses on a electrocardiogram-gated multishot echo-planar imaging sequence, using the simple strategy of using the intrinsic T1 weighting produced by a repetition time equal to the heart period. To quantitate the sequence's performance with respect to normal myocardial perfusion, seven volunteers were imaged, each with three different doses of the contrast medium gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA). The first-pass dynamics of the contrast were quantified in 13 regions per heart for each examination. In all volunteers, the complete heart could be covered, with five to seven slices, every two heartbeats. Enhancement was homogeneous throughout the left ventricular myocardium, with an enhancement of approximately 50% for the optimum contrast dose of 0.05 mmol/kg Gd-DTPA.
本文提出了一种用于评估心肌灌注的新型磁共振成像策略。此前的大多数工作都依赖于使用T1加权快速梯度回波成像来动态监测造影剂团注通过期间的信号变化。然而，梯度回波方法受到无法以足够的时间分辨率对整个心脏成像的限制。本文重点介绍一种心电图门控多激发回波平面成像序列，采用重复时间等于心动周期所产生的固有T1加权这一简单策略。为了量化该序列在正常心肌灌注方面的性能，对7名志愿者进行了成像，每名志愿者使用三种不同剂量的造影剂钆喷酸葡胺（Gd-DTPA）。每次检查时，在每个心脏的13个区域对造影剂的首过动力学进行量化。在所有志愿者中，每两个心跳可以用五到七个层面覆盖整个心脏。左心室心肌的强化是均匀的，对于0.05 mmol/kg Gd-DTPA的最佳造影剂剂量强化约为50%。
