Xulin S, Ito A, Tateishi T, Hoshino A
National Institute for Advanced Interdisciplinary Research, Ministry of International Trade and Industry, Ibaraki, Japan.
J Biomed Mater Res. 1997 Jan;34(1):9-14. doi: 10.1002/(sici)1097-4636(199701)34:1<9::aid-jbm2>3.0.co;2-v.
To avoid nickel ion release from SUS317L as an implant material, a new type of nickel, commercially free, of high purity, and high chromium ferritic stainless steel, was developed. The new stainless steel (FJ) was studied for aspects of fretting corrosion and cytocompatibility compared with SUS317L. A pin-on-plate fretting corrosion test in an artificial physiologic solution, and cell culture in media with the addition of the artificial physiologic solution used for fretting was conducted. Resistance to the fretting induced crevice corrosion of FJ was higher than that of SUS317L because of the favorable electrochemical stability of the FJ alloy. The amount of iron ion or colloidal fine particles released from FJ was about a quarter of that from SUS317L, although the weight loss of a pin of FJ was almost 5/3 that of SUS317L. The artificial physiologic solution used for SUS317L fretting was more harmful to the growth of L929 and MC3T3-E1 cells than that used for FJ fretting. FJ was therefore superior to SUS317L as a biomaterial, judging from the resistance to fretting-induced crevice corrosion, electrochemical stability, and the cytocompatibility of fretting corrosion products.
为避免作为植入材料的SUS317L释放镍离子，研发了一种新型的、商业上无镍、高纯度且高铬的铁素体不锈钢。将这种新型不锈钢（FJ）与SUS317L进行了微动腐蚀和细胞相容性方面的研究。在人工生理溶液中进行了销盘式微动腐蚀试验，并在添加了用于微动试验的人工生理溶液的培养基中进行了细胞培养。由于FJ合金具有良好的电化学稳定性，FJ对微动诱发缝隙腐蚀的抗性高于SUS317L。尽管FJ销的失重几乎是SUS317L的5/3，但从FJ释放的铁离子或胶体细颗粒的量约为SUS317L的四分之一。用于SUS317L微动试验的人工生理溶液对L929和MC3T3-E1细胞生长的危害比对FJ微动试验的溶液更大。因此，从对微动诱发缝隙腐蚀的抗性、电化学稳定性以及微动腐蚀产物的细胞相容性来看，FJ作为生物材料优于SUS317L。
