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Correction of the spontaneous and DEB-induced chromosomal aberrations in Fanconi anemia cells of the FA(C) complementation group by the FACC gene.

作者信息

Stavropoulos D J, Sood S, Tomkins D J, Buchwald M

机构信息

Department of Biology, McMaster University, Hamilton, Ont. Canada.

出版信息

Cytogenet Cell Genet. 1996;72(2-3):194-6. doi: 10.1159/000134187.

DOI:10.1159/000134187
PMID:8978774
Abstract

Fanconi anemia (FA) cells are hypersensitive to the cytotoxic and clastogenic effects of DNA cross-linking agents. Four complementation groups have been identified to date. The gene (FACC) that corrects the hypersensitivity of one of them, FA(C), has been cloned. In the present study, both the increased spontaneous and diepoxybutane (DEB)-induced chromosomal instability in FA(C) lymphoblastoid cells were corrected by transfection of FACC.

摘要

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