Kanazawa K, Moromizato H
Dept. of Obstetrics and Gynecology, Faculty of Medicine, University of The Ryukyus.
Gan To Kagaku Ryoho. 1996 Dec;23(14):1925-8.
Clinical application of etoposide (VP-16) for gynecologic malignancy has been investigated in trophoblastic disease, ovarian, endometrial and cervical cancer. Etoposide has proved to be one of the most effective agents for trophoblastic disease. It is widely used in single or multiple drug regimens in chemotherapy of the disease. Furthermore, this drug is observed to be active in the combination of BLM with CDDP for germ cell tumor of the ovary. It is now playing an important role in chemotherapy of this tumor.
依托泊苷（VP - 16）在妇科恶性肿瘤中的临床应用已在滋养细胞疾病、卵巢癌、子宫内膜癌和宫颈癌中进行了研究。依托泊苷已被证明是治疗滋养细胞疾病最有效的药物之一。它广泛用于该疾病化疗的单药或多药方案中。此外，观察到该药物在博来霉素与顺铂联合治疗卵巢生殖细胞肿瘤中具有活性。它目前在这种肿瘤的化疗中发挥着重要作用。
