口服双膦酸盐对大鼠废用性骨质减少模型骨丢失的影响。
Effects of orally administered bisphosphonates on bone loss in a disuse osteopenia model involving the rat.
作者信息
Mian M, Benetti D, Aloisi R, Rosini S, Fantozzi R, Savarino L, Stea S, Donati M E, Paganetto G, Pizzoferrato A
机构信息
Gentili Institute, Research Division, Pisa, Italy.
出版信息
Clin Exp Rheumatol. 1996 Nov-Dec;14(6):619-24.
OBJECTIVE
This study was carried out to evaluate the effectiveness of two newly synthesized bisphosphonates (BPs) [Alendronate (4-amino-1-hydroxybutylidene-1, 1-bisphosphonic acid (AHBuBP)) and Neridronate (6-amino-1-hydroxyhexylidene-1,1-bisphosphonic acid (AHHexBP)], administered orally, in reducing experimentally induced bone loss.
METHODS
Unilateral sciatic nerve section was performed on the Sprague-Dawley rat to induce osteopenia in one of the hind limbs. Histomorphometric measurements of the tibial trabecular bone and femur ash content determinations were effected to assess the degree of osteopenia. For comparison Chlodronate (dichloromethylene-1-bisphosphonic acid (Cl2MBP) was employed as the reference drug.
CONCLUSIONS
The results of this investigation show that both BPs were significantly active in reducing the osteopenic process in the involved limb and were more active than Chlodronate.
目的
本研究旨在评估两种新合成的双膦酸盐（BPs）[阿仑膦酸盐（4-氨基-1-羟基丁叉-1,1-双膦酸（AHBuBP））和奈立膦酸盐（6-氨基-1-羟基己叉-1,1-双膦酸（AHHexBP））]口服给药对减少实验性诱导的骨质流失的有效性。
方法
对Sprague-Dawley大鼠进行单侧坐骨神经切断术，以诱导一侧后肢出现骨质减少。通过对胫骨小梁骨进行组织形态计量学测量和测定股骨灰分含量来评估骨质减少的程度。为作比较，使用氯膦酸盐（二氯亚甲基-1-双膦酸（Cl2MBP））作为参比药物。
结论
本研究结果表明，两种双膦酸盐在减少受累肢体的骨质减少过程中均具有显著活性，且比氯膦酸盐活性更强。
Zotero 插件