Mannuci P M, Tripodi A
Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center, Institute of Internal Medicine, Milano, Italy.
Haemostasis. 1996 Oct;26 Suppl 4:1-8. doi: 10.1159/000217279.
Information on hypercoagulability can be achieved through the measurement of peptides that are generated when zymogens are activated, of the active enzymes, or of the complexes that form in the circulation when enzymes are inactivated by their plasmatic inhibitors. These assay methods have dramatically improved our understanding of the mechanisms which regulate coagulation in health and disease. However, their choice and use as predictors of thrombotic events and to monitor anticoagulant treatment still need to be defined in prospective clinical trials.
酶原激活时产生的肽段、活性酶，或酶被血浆抑制剂灭活时在循环中形成的复合物。这些检测方法极大地增进了我们对健康和疾病状态下调节凝血机制的理解。然而，它们作为血栓形成事件预测指标以及监测抗凝治疗的选择和应用，仍有待在前瞻性临床试验中加以明确。
