Ireland H, Kyriakoulis K, Kunz G, Lane D A
Department of Haematology, Charing Cross and Westminster Medical School, London.
Haemostasis. 1996 Oct;26 Suppl 4:227-32. doi: 10.1159/000217303.
Thrombomodulin is a principle thrombin receptor located on the vascular endothelium. Thrombomodulin alters the specificity of thrombin, redirecting its procoagulant function to an anticoagulant function by making it a more efficient activator of protein C. While mutation of the genes of other components of this anticoagulant mechanism, protein C, protein S and factor V, is known to predispose towards venous thromboembolism, there are only a few reports of the investigation of thrombomodulin gene mutation. We present the design and evaluation of a strategy to investigate thrombomodulin gene mutation in arterial and venous thrombosis.
血栓调节蛋白是位于血管内皮的主要凝血酶受体。血栓调节蛋白改变凝血酶的特异性，通过使其成为蛋白C更有效的激活剂，将其促凝血功能转变为抗凝血功能。虽然已知这种抗凝血机制的其他成分，即蛋白C、蛋白S和因子V的基因突变易导致静脉血栓栓塞，但关于血栓调节蛋白基因突变的研究报告却很少。我们展示了一种用于研究动脉和静脉血栓形成中血栓调节蛋白基因突变的策略的设计与评估。
