Stefanova P, Dimova P
Clinic of Paediatric Surgery, University of Medicine, Plovdiv, Bulgaria.
Folia Med (Plovdiv). 1996;38(1):69-73.
The study was carried out on a material obtained by a biopsy from 18 children having different types of hemangiomas (capillary, cavernous and combined). Histochemical reactions were applied for the following enzymes: Succenatedehydrogenase (SDH), lactatdehydrogenase (LDH), cytochromoxidase, acid phosphatase, alkaline phosphatase and paraspecific esterases. Differently reduced activity of the succenatedehydrogenase and the cytochromoxidase in the endothelial cells and the pericytes was established. A reduced enzyme activity was observed also in a large part of the cases of acid phosphatase. The activity of the alkaline phosphatase and paraspecific esterases was greatly increased. Based on their observations the authors relate the hemangiomas to the tumour formations with a good prognosis.
该研究对取自18名患有不同类型血管瘤（毛细血管型、海绵状和混合型）儿童的活检材料进行。对以下酶进行了组织化学反应：琥珀酸脱氢酶（SDH）、乳酸脱氢酶（LDH）、细胞色素氧化酶、酸性磷酸酶、碱性磷酸酶和副特异性酯酶。发现内皮细胞和周细胞中琥珀酸脱氢酶和细胞色素氧化酶的活性有不同程度降低。在大部分酸性磷酸酶病例中也观察到酶活性降低。碱性磷酸酶和副特异性酯酶的活性大大增加。基于他们的观察结果，作者将血管瘤归为预后良好的肿瘤形成类型。
