Singewald N, Philippu A
Department of Pharmacology and Toxicology, University of Innsbruck, Austria.
Trends Pharmacol Sci. 1996 Oct;17(10):356-63.
Biogenic amines and amino acids have been implicated in central cardiovascular homeostasis. Initially, drugs were injected into the brain and their effects on blood pressure were investigated. Other approaches allowed endogenous neurotransmitters released in the extracellular space of brain structures involved in cardiovascular regulation to be identified. As Nicolas Singewald and Athineos Philippu outline, even slight disturbances in blood pressure and/or isovolaemia lead to marked changes in the release rates of biogenic amines and amino acids in various brain structures. Blood pressure homeostasis is maintained with the participation of several brain regions and neurotransmitters which possess the same or opposing functions when released from CNS neurones.
生物胺和氨基酸与中枢心血管稳态有关。最初，将药物注入大脑并研究其对血压的影响。其他方法可以识别在参与心血管调节的脑结构细胞外空间中释放的内源性神经递质。正如尼古拉斯·辛格瓦尔德和阿西内奥斯·菲利普所概述的，即使血压和/或血容量的轻微扰动也会导致各种脑结构中生物胺和氨基酸释放率的显著变化。血压稳态在几个脑区和神经递质的参与下得以维持，这些脑区和神经递质从中枢神经系统神经元释放时具有相同或相反的功能。
