Volpe B T, Blau A D, Wessel T C, Saji M
Department of Neurology and Neuroscience, Cornell University Medical Centre at the Winifred Masterson Burke Research Institute, White Plains, New York 10605, USA.
Neurobiol Dis. 1995 Apr;2(2):119-27. doi: 10.1006/nbdi.1995.0012.
Neurones in the rat substantia nigra compacta (SNC) are initially resistant to transient forebrain ischaemia in contrast to vulnerable neurones in the striatum that die within 24 h. Animals were exposed to 20 min of four vessel occlusion and killed 1 and 3 weeks after reperfusion. All ischaemic animals had striatal neurone loss. Analysis of the number of tyrosine hydroxylase immunoreactive neurones (THir) in the SNC was comparable between controls and ischaemic animals killed 1 week after reperfusion. However, there was a significant reduction in THir neurone number (24%), SNC volume (17%), and THir dendritic arborization in the substantia nigra reticulata (SNR) that occurred 3 weeks after reperfusion, despite the persistence of THir axons in the striatum. Detailed morphological analysis of areas distant from the initial ischaemic injury suggest delayed degeneration may play an important role in the brain's response to ischaemia, and may provide insights for clinical stroke treatment and management.
与纹状体中在24小时内死亡的易损神经元不同，大鼠黑质致密部（SNC）的神经元最初对短暂性前脑缺血具有抗性。将动物暴露于四血管闭塞20分钟，并在再灌注后1周和3周处死。所有缺血动物均有纹状体神经元丢失。再灌注后1周处死的对照组和缺血动物之间，SNC中酪氨酸羟化酶免疫反应性神经元（THir）数量的分析结果相当。然而，再灌注3周后，尽管纹状体中THir轴突持续存在，但黑质网状部（SNR）的THir神经元数量显著减少（24%），SNC体积减少（17%），且THir树突分支减少。对远离初始缺血损伤区域的详细形态学分析表明，延迟性变性可能在大脑对缺血的反应中起重要作用，并可能为临床中风治疗和管理提供见解。
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