Tuszynski G P, Wang T N, Berger D
Department of Surgery, Medical College of Pennsylvania, Philadelphia, USA.
Acta Haematol. 1997;97(1-2):29-39. doi: 10.1159/000203657.
The metastatic spread of cancer is a complex and multistep process characterized by a number of biological steps which include the hematogenous and lymphatic arrest and adhesion of circulating tumor cells in the vascular bed, invasion of tumor cells through the basement membrane, and growth of new tumor colonies in the organ parenchyma. In this brief review we describe the role of platelets, the hemostatic system, adhesive proteins and their putative receptors in the hematogenous dissemination of cancer. The major adhesive proteins postulated to play a role in tumor arrest in the vascular bed are thrombospondin-1 (TSP-1), laminin, fibronectin and hyaluronan-proteoglycans. The major tumor and vascular receptors mediating these adhesive interactions are the CSVTCG-specific TSP-1 receptor, the 67-kD laminin receptor, the alpha v beta 3 vitronectin/TSP-1/fibronectin receptor, and CD44 hyaluronan receptor. The discovery of the involvement of these adhesive proteins and receptors in the metastatic spread of cancer as well as components of the hemostatic system offers unique opportunities for the development of antimetastasis therapies for the treatment of cancer.
癌症的转移扩散是一个复杂的多步骤过程，其特征在于多个生物学步骤，包括循环肿瘤细胞在血管床中的血行性和淋巴性停滞与黏附、肿瘤细胞穿过基底膜的侵袭以及器官实质中新肿瘤集落的生长。在这篇简短的综述中，我们描述了血小板、止血系统、黏附蛋白及其假定受体在癌症血行播散中的作用。据推测，在血管床中肿瘤停滞过程中起作用的主要黏附蛋白是血小板反应蛋白-1（TSP-1）、层粘连蛋白、纤连蛋白和透明质酸-蛋白聚糖。介导这些黏附相互作用的主要肿瘤和血管受体是CSVTCG特异性TSP-1受体、67-kD层粘连蛋白受体、αvβ3玻连蛋白/TSP-1/纤连蛋白受体以及CD44透明质酸受体。这些黏附蛋白和受体参与癌症转移扩散以及止血系统成分的发现，为开发用于治疗癌症的抗转移疗法提供了独特的机会。
