Bluthé R M, Michaud B, Kelley K W, Dantzer R
INRA-INSERM U394, Domaine de Carreire, Bordeaux, France.
Neuroreport. 1996 Nov 4;7(15-17):2823-7. doi: 10.1097/00001756-199611040-00083.
To test specificity of the involvement of vagal afferents in the communication between the immune system and the brain, sham-operated and vagotomized mice were injected i.p., s.c. or i.v. with physiological saline or interleukin-1 beta (IL-1 beta [symbol: see text] 4 weeks after surgery. Vagotomy attenuated the decrease in social exploration induced by i.p. injection of 300 ng recombinant human IL-1 beta but had no effect when IL-1 beta was injected s.c. (300 ng) or i.v. (500 ng). Vagotomy also attenuated the depression in social investigation induced by i.p. injection of recombinant rat IL-1 beta (IL-1 beta, 1 microgram) but was without effect when 1 microgram IL-1 beta was injected i.v. These results confirm the role of vagal afferent nerves in the transmission of an immune message from the periphery to the brain and show that the vagus nerve only conveys information concerning cytokines injected into the abdominal cavity.
为了测试迷走神经传入纤维在免疫系统与大脑之间通讯中的参与特异性，在手术后4周，对假手术组和迷走神经切断组小鼠进行腹腔注射、皮下注射或静脉注射生理盐水或白细胞介素-1β（IL-1β [符号：见正文]）。迷走神经切断减弱了腹腔注射300 ng重组人IL-1β诱导的社会探索减少，但皮下注射（300 ng）或静脉注射（500 ng）IL-1β时则无影响。迷走神经切断也减弱了腹腔注射重组大鼠IL-1β（IL-1β，1 μg）诱导的社会探究抑制，但静脉注射1 μg IL-1β时则无作用。这些结果证实了迷走神经传入神经在将免疫信息从外周传递到大脑中的作用，并表明迷走神经仅传递有关注入腹腔的细胞因子的信息。
