Port F K, Wolfe R A, Bloembergen W E, Held P J, Young E W
University of Michigan Department of Medicine, School of Medicine, Ann Arbor, USA.
Perit Dial Int. 1996 Nov-Dec;16(6):628-33.
To discuss potential reasons for reported differences in the results of several recent studies comparing mortality risk among continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis patients, and to assess the role of statistical methods and study design.
Recent published reports comparing mortality risk among patients treated with CAPD and hemodialysis.
Differences in study design, study populations, sample size, data collection, and availability of data likely account in part for the differences in available study results. The Cox model is a valuable tool, particularly for observational studies. Observed outcome differences for CAPD and hemodialysis patients may be due to either the dialytic modality itself or other factors such as differences in patient selection, practice patterns, dialysis dose, patient compliance, etc. Relative mortality rates for hemodialysis and CAPD patients may vary by country, as these factors may differ internationally. A randomized clinical trial is necessary to best determine the effect of the modality itself.
探讨近期多项比较持续性非卧床腹膜透析（CAPD）患者与血液透析患者死亡风险的研究结果存在差异的潜在原因，并评估统计方法和研究设计的作用。
近期发表的比较CAPD治疗患者与血液透析治疗患者死亡风险的报告。
研究设计、研究人群、样本量、数据收集以及数据可用性方面的差异可能在一定程度上解释了现有研究结果的差异。Cox模型是一种有价值的工具，尤其适用于观察性研究。CAPD患者和血液透析患者观察到的结局差异可能是由于透析方式本身，也可能是由于其他因素，如患者选择、实践模式、透析剂量、患者依从性等方面的差异。血液透析患者和CAPD患者的相对死亡率可能因国家而异，因为这些因素在国际上可能有所不同。有必要进行一项随机临床试验，以最好地确定透析方式本身的效果。
