心肌缺血期间的血小板活化：一种促心律失常机制。

Platelet activation during myocardial ischaemia: a contributory arrhythmogenic mechanism.

作者信息

Flores N A

机构信息

Academic Cardiology Unit, Imperial College School of Medicine at St. Mary's, London, UK.

出版信息

Pharmacol Ther. 1996;72(2):83-108. doi: 10.1016/s0163-7258(96)00100-3.

DOI:10.1016/s0163-7258(96)00100-3

PMID:8981572

Abstract

Experimental and clinical observations of the involvement of platelets in the pathophysiology of myocardial ischaemia indicate the importance of interactions between these formed elements and the heart. The aim of this review is to outline evidence linking platelet activation, myocardial ischaemia and infarction, and to present evidence for a link between platelet activation, arrhythmogenesis and sudden death. A brief review of platelet physiology and pharmacology is provided, with a review of the cardiac electrophysiological effects of ischaemia and the electrophysiological effects of platelet-derived substances. The concept that platelet activation during myocardial ischaemia is a contributory arrhythmogenic mechanism is discussed.

摘要

关于血小板参与心肌缺血病理生理学过程的实验和临床观察表明，这些血液有形成分与心脏之间相互作用具有重要意义。本综述的目的是概述血小板活化、心肌缺血和梗死之间联系的证据，并提供血小板活化、心律失常发生和猝死之间存在关联的证据。文中简要回顾了血小板生理学和药理学，并综述了缺血对心脏电生理的影响以及血小板衍生物质的电生理效应。还讨论了心肌缺血期间血小板活化是心律失常发生的一个促成机制这一概念。