Hjalmarsen A, Aasebø U, Aakvaag A, Jorde R
Department of Pulmonary Medicine, University Hospital of Tromsø, Norway.
Scand J Clin Lab Invest. 1996 Nov;56(7):635-40. doi: 10.3109/00365519609090598.
The responses of serum testosterone, sex hormone-binding globulin (SHBG) and luteinizing hormone (LH) to an oral glucose tolerance test (OGTT) were investigated in 16 healthy subjects as well as in 11 normoxaemic and 10 hypoxaemic chronic obstructive pulmonary disease (COPD) patients. The latter group were investigated on two occasions, with and without oxygen therapy. Testosterone and apparent free testosterone concentration (AFTC) fell significantly in the healthy subjects as well as in the hypoxaemic patients on oxygen therapy (p < 0.01), whereas LH increased in all groups during the OGTT (p < 0.05). There were significantly higher SHBG levels (p < 0.01), and lower AFTC levels (p < 0.05) in the hypoxaemic group compared to the healthy subjects. In the hypoxaemic group short-term oxygen therapy increased basal AFTC significantly (p < 0.05). With oxygen therapy, the 120-min glucose levels fell significantly from 9.1 +/- 3.2 to 7.6 +/- 2.7 mmol l-1 (mean +/- SD) in the hypoxaemic group (p < 0.05). In conclusion, we have found the serum testosterone and AFTC levels to decrease after an oral glucose load in healthy subjects, together with a compensatory increase in LH. The same pattern is seen in COPD patients. The hypoxaemic patients have a reduced AFTC which is partly reversed by oxygen therapy.
我们对16名健康受试者、11名血氧正常的慢性阻塞性肺疾病（COPD）患者以及10名低氧血症的COPD患者进行了研究，观察血清睾酮、性激素结合球蛋白（SHBG）和促黄体生成素（LH）对口服葡萄糖耐量试验（OGTT）的反应。后一组患者在接受和未接受氧疗的两种情况下接受了研究。健康受试者以及接受氧疗的低氧血症患者的睾酮和表观游离睾酮浓度（AFTC）显著下降（p<0.01），而在OGTT期间所有组的LH均升高（p<0.05）。与健康受试者相比，低氧血症组的SHBG水平显著更高（p<0.01），AFTC水平更低（p<0.05）。在低氧血症组中，短期氧疗显著提高了基础AFTC（p<0.05）。接受氧疗后，低氧血症组的120分钟血糖水平从9.1±3.2显著降至7.6±2.7 mmol l-1（平均值±标准差）（p<0.05）。总之，我们发现健康受试者口服葡萄糖负荷后血清睾酮和AFTC水平下降，同时LH代偿性增加。COPD患者也出现同样的模式。低氧血症患者的AFTC降低，氧疗可部分逆转这一情况。
