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3,6-二取代的1,2,4-三唑并[3,4-b][1,3,4]噻二唑：合成、抗菌和抗病毒活性。II.

3,6-Disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles: synthesis, antimicrobial and antiviral activity. II.

作者信息

Invidiata F P, Simoni D, Scintu F, Pinna N

机构信息

Istituto Farmacochimico dell'Università di Palermo, Italy.

出版信息

Farmaco. 1996 Oct;51(10):659-64.

PMID:8981756
Abstract

A series of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4] thiadiazole derivatives was prepared and tested to evaluate their antimycotic and antibacterial activities. Anti-HIV-1 activity has also been investigated. Among the test compounds, derivatives 10a-14a and 16c showed anti-HIV-1 activity at concentrations slightly below those cytotoxic. Substitutions at 3 and 6 positions seems to be important in lowering the cytotoxicity of compounds.

摘要

制备了一系列新型的3,6-二取代-1,2,4-三唑并[3,4-b][1,3,4]噻二唑衍生物，并对其抗真菌和抗菌活性进行了测试。还研究了其抗HIV-1活性。在测试化合物中，衍生物10a - 14a和16c在浓度略低于细胞毒性浓度时表现出抗HIV-1活性。3位和6位的取代对于降低化合物的细胞毒性似乎很重要。

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