一些N，N-二取代的1-氨基-2-苯基-3H，12H-萘并[1,2-b]吡喃并[2,3-d]吡喃-3-酮的合成与药理活性
Synthesis and pharmacological activity of some N,N-disubstituted 1-amino-2-phenyl-3H,12H-naphtho[1,2-b]pyrano[2,3-d]pyran-3-ones.
作者信息
Longobardi M, Bargagna A, Mariani E, Filippelli W, Falcone G, Marabese I
机构信息
Istituto di Scienze Farmaceutiche dell' Università, Genova, Italy.
出版信息
Farmaco. 1996 Oct;51(10):665-8.
PMID:8981757
Abstract
The synthesis of some N,N-disubstituted 1-amino-2-phenyl-3H,12H-naphtho[1,2-b]pyrano[2,3-d]pyran-3-ones 4, by reaction of phenylchloroketene with a series of N,N-disubstituted 3-aminomethylene-2,3-dihydro-4H-naphtho[1,2-b]pyran-4-ones, followed by dehydrochlorination in situ of the primary adducts with DBN, is described. Some compounds 4 showed antiarrhythmic and analgesic activities.
摘要
通过苯基氯代乙烯酮与一系列N,N-二取代的3-氨基亚甲基-2,3-二氢-4H-萘并[1,2-b]吡喃-4-酮反应，随后用DBN对初级加合物进行原位脱氯化氢反应，描述了一些N,N-二取代的1-氨基-2-苯基-3H,12H-萘并[1,2-b]吡喃并[2,3-d]吡喃-3-酮4的合成。一些化合物4表现出抗心律失常和镇痛活性。
Zotero 插件