Longobardi M, Bargagna A, Mariani E, Schenone P, D'Amico M, Falciani M, Filippelli W, Contaldi C
Istituto di Farmacologia e Tossicologia, Facoltà di Medicina e Chirurgia, II Università degli studi di Napoli, Italy.
Farmaco. 1995 Jan;50(1):55-9.
The synthesis of some N,N-disubstituted 4-amino-5,6,7,8,9,10-hexahydro-3- phenyl-2H-cycloocta[b]pyran-2-ones by reaction of phenylchloroketene with a series of N,N-disubstituted 2-aminomethylenecyclooctanones, followed by dehydrochlorination in situ of the primary adducts with DBN, is described. The dimethylamino derivative showed a local anesthetic activity in mice superior to that of lidocaine, and some compounds exhibited a platelet antiaggregating activity in vitro superior or comparable to that of acetylsalicylic acid, as well as weak antiarrhythmic and antiinflammatory activities in rats.
