由于胰岛素分泌的混杂因素，空腹胰岛素水平会低估非胰岛素依赖型糖尿病的风险。

Fasting insulin level underestimates risk of non-insulin-dependent diabetes mellitus due to confounding by insulin secretion.

作者信息

Boyko E J, Leonetti D L, Bergstrom R W, Fujimoto W Y

机构信息

Department of Medicine, University of Washington School of Medicine, Seattle, USA.

出版信息

Am J Epidemiol. 1997 Jan 1;145(1):18-23. doi: 10.1093/oxfordjournals.aje.a009027.

DOI:10.1093/oxfordjournals.aje.a009027

PMID:8982018

Abstract

Fasting insulin has been used as a surrogate measure of insulin sensitivity in studies of non-insulin-dependent diabetes mellitus (NIDDM) risk, but the fasting insulin-NIDDM association may be confounded by insulin secretion, which correlates negatively with NIDDM risk and positively with fasting insulin level. In a prospective 5-year study of 137 nondiabetic Japanese-American men in King County, Washington State, higher fasting insulin was not strongly related to NIDDM (odds ratio (OR) = 1.37, 95% confidence interval (CI) 0.80-2.34), but this odds ratio increased substantially after adjustment for insulin secretion (OR = 2.92, 95% CI 1.41-6.06). Research on NIDDM risk in relation to fasting insulin may yield biased effect measures unless adjusted for insulin secretion.

摘要

在非胰岛素依赖型糖尿病（NIDDM）风险研究中，空腹胰岛素一直被用作胰岛素敏感性的替代指标，但空腹胰岛素与NIDDM之间的关联可能会受到胰岛素分泌的干扰，胰岛素分泌与NIDDM风险呈负相关，与空腹胰岛素水平呈正相关。在华盛顿州金县对137名非糖尿病日裔美国男性进行的一项为期5年的前瞻性研究中，较高的空腹胰岛素与NIDDM并无强烈关联（优势比（OR）= 1.37，95%置信区间（CI）0.80 - 2.34），但在对胰岛素分泌进行调整后，该优势比大幅增加（OR = 2.92，95%CI 1.41 - 6.06）。除非对胰岛素分泌进行调整，否则关于空腹胰岛素与NIDDM风险的研究可能会得出有偏差的效应量。