Källén B, Nilsson O
Allergy. 1979 Apr 2;34(2):97-102. doi: 10.1111/j.1398-9995.1979.tb01369.x.
The reactivity to three antigens: bovine encephalitogenic protein (EP), PPD, and tetanus toxoid, was studied with blood leukocytes from healthy humans using Clausen's (5) leukocyte migration in agarose technique. There is an obvious correlation between the reaction of EP (all concentrations studied) and to low concentrations of PPD; and between the reactivity to low concentrations of EP and low concentrations of tetanus toxoid. After vaccination with tetanus vaccine, a marked increase in reactivity to the toxoid sometimes occurred; at the same time, a marked reactivity to EP appeared. Various explanations are discussed: a true immunological cross-reactivity, that the correlations are due to a variability in individual response with respect to lymphokine production, and that BCG and tetanus vaccinations produce an adjuvant effect increasing a pre-existing low reactivity to EP.
使用克劳森（5）的琼脂糖中白细胞迁移技术，研究了健康人血液白细胞对三种抗原的反应性：牛致脑炎性蛋白（EP）、结核菌素纯蛋白衍生物（PPD）和破伤风类毒素。在EP（所有研究浓度）与低浓度PPD的反应之间；以及低浓度EP与低浓度破伤风类毒素的反应性之间，存在明显的相关性。接种破伤风疫苗后，有时会出现对类毒素反应性的显著增加；同时，对EP出现显著反应。讨论了各种解释：真正的免疫交叉反应性、相关性是由于个体对淋巴因子产生反应的变异性，以及卡介苗和破伤风疫苗接种产生佐剂效应，增加了先前存在的对EP的低反应性。
