Sugimoto Y, Yamada J, Yoshikawa T, Noma T, Horisaka K
Department of Pharmacology, Kobe Pharmaceutical University, Japan.
Eur J Pharmacol. 1996 Nov 28;316(1):15-21. doi: 10.1016/s0014-2999(96)00660-7.
Peripherally administered, the 5-HT2 receptor agonist, alpha-methyl-5-hydroxytryptamine (alpha-methyl-5-HT), significantly suppressed the food intake of food-deprived rats. alpha-Methyl-5-HT also inhibited 2-deoxy-D-glucose-induced hyperphagia in rats. The alpha-methyl-5-HT-induced hypophagia was antagonized by the 5-HT2A receptor antagonist, ketanserin. The alpha-methyl-5-HT-induced decrease in food intake of food-deprived rats was not inhibited by prior adrenodemedullation. The peripheral 5-HT3 receptor agonist, 2-methyl-5-HT, did not affect food intake in food-deprived or 2-deoxy-D-glucose-treated rats. These results suggest that the peripheral 5-HT2A receptor may participate in the regulation of food intake and that its hypophagic effects are not associated with its adrenaline-releasing effects from the adrenal gland. Lastly, the peripheral 5-HT3 receptor did not participate in feeding control.
外周给予5-羟色胺2（5-HT2）受体激动剂α-甲基-5-羟色胺（α-甲基-5-HT）可显著抑制饥饿大鼠的食物摄入量。α-甲基-5-HT还可抑制大鼠由2-脱氧-D-葡萄糖诱导的摄食亢进。5-HT2A受体拮抗剂酮色林可拮抗α-甲基-5-HT诱导的摄食减少。预先进行肾上腺髓质切除并不能抑制α-甲基-5-HT诱导的饥饿大鼠食物摄入量的减少。外周5-HT3受体激动剂2-甲基-5-HT对饥饿或经2-脱氧-D-葡萄糖处理的大鼠的食物摄入量没有影响。这些结果表明，外周5-HT2A受体可能参与食物摄入的调节，其导致摄食减少的作用与其从肾上腺释放肾上腺素的作用无关。最后，外周5-HT3受体不参与进食控制。
