Moss M B, Killiany R J, Lai Z C, Rosene D L, Herndon J G
Department of Anatomy and Neurobiology, Boston University School of Medicine, MA 02118, USA.
Neurobiol Aging. 1997 Jan-Feb;18(1):13-9. doi: 10.1016/s0197-4580(96)00211-4.
Assessment of recognition memory was performed on eight rhesus monkeys of advanced age (25 to 27 years of age) using the delayed recognition span test (DRST). Their performance was compared to that of five young adult animals (5 to 7 years of age) on two stimulus conditions of the DRST: spatial position and color. Both trial unique and repeating series were used for each of the two conditions. As a group, aged monkeys were impaired on both the spatial and color conditions of the DRST, achieving about two-thirds of the span of the young adult group in each condition. Error analyses revealed that monkeys in the aged group also produced more perseverative responses (i.e., displacing the previously correct disk) than did young adults. Together the findings suggest that monkeys of advanced age are impaired on tasks with memory loading demand characteristics.
使用延迟识别跨度测试（DRST）对八只高龄（25至27岁）恒河猴的识别记忆进行了评估。在DRST的两种刺激条件下，即空间位置和颜色条件下，将它们的表现与五只年轻成年动物（5至7岁）的表现进行了比较。两种条件下均使用了每次试验独特和重复系列。作为一个群体，老年猴子在DRST的空间和颜色条件下均受损，在每种条件下达到年轻成年组跨度的约三分之二。错误分析显示，老年组的猴子比年轻成年猴子产生更多的持续性反应（即移动先前正确的圆盘）。这些发现共同表明，高龄猴子在具有记忆负荷需求特征的任务上受损。
