Tahara E
First Department of Pathology, Hiroshima University School of Medicine, Japan.
Princess Takamatsu Symp. 1994;24:187-94.
Stomach cancer shows multiple gene changes, including both oncogenes and tumor suppressor genes. Among them, the one most frequently implicated in stomach cancer is the abnormal expression and amplification of the c-met gene. Moreover, stomach cancer cells express a broad spectrum of growth factors and cytokines that not only serve autocrine or paracrine growth of tumor cells, but also organize the complex networks between tumor cells and stromal cells. However, the scenario of cancer-stromal interaction differs depending on the two histological types-the well-differentiated or intestinal type and the poorly-differentiated or diffuse type-as the two types of stomach cancer may have different genetic pathways. The interaction between cell-adhesion molecules in the c-met overexpressed tumor cells and HGF from activated fibroblast may be involved in the progression and the morphogenesis of stomach cancer.
胃癌表现出多种基因变化，包括癌基因和肿瘤抑制基因。其中，与胃癌关系最密切的是c-met基因的异常表达和扩增。此外，胃癌细胞表达多种生长因子和细胞因子，这些因子不仅促进肿瘤细胞的自分泌或旁分泌生长，还能构建肿瘤细胞与基质细胞之间的复杂网络。然而，癌症与基质相互作用的情况因两种组织学类型而异，即高分化或肠型以及低分化或弥漫型，因为这两种类型的胃癌可能具有不同的遗传途径。c-met过表达的肿瘤细胞中的细胞粘附分子与活化成纤维细胞产生的HGF之间的相互作用可能参与了胃癌的进展和形态发生。
