Dunn A R, Mann G B, Fowler K J, Grail D, Hibbs M L, Alexander W S, Walker F, Burgess A W
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia.
Princess Takamatsu Symp. 1994;24:276-89.
Transforming growth factor alpha (TGF alpha) is one of a group of structurally-related growth factors (the epidermal growth factor family of ligands) that interact with one or other members of the epidermal growth factor family of protein tyrosine kinase receptors (EGF-R's). A number of excellent reviews detailing our knowledge of this area have been recently published (Carpenter and Wahl, 1991; Derynck, 1992; Prigent and Lemoine, 1992). Rather than add to their number, this review focuses on new insights into the importance of TGF alpha and signaling through the EGF receptor considered in the context of the laboratory mouse. The new information has emerged from analysis of mutant mice generated either by classical gene targeting in embryonic stem (ES) cells or by accidents of nature. In addition to their intrinsic interest, these mice are proving invaluable in determining the importance of EGF receptor signaling in wound healing and as a contributing factor in the conversion of a normal cell into its tumorigenic counterpart.
转化生长因子α（TGFα）是一组结构相关的生长因子（表皮生长因子配体家族）之一，它与蛋白酪氨酸激酶受体（EGF-R）的表皮生长因子家族的一个或其他成员相互作用。最近发表了许多详细阐述我们对该领域认识的优秀综述（卡彭特和瓦尔，1991年；德林克，1992年；普里让和勒莫因，1992年）。本综述并非增加其数量，而是聚焦于在实验室小鼠背景下对TGFα的重要性以及通过EGF受体进行信号传导的新见解。这些新信息来自对通过胚胎干细胞中的经典基因靶向或自然偶然事件产生的突变小鼠的分析。除了它们本身的趣味性之外，这些小鼠在确定EGF受体信号传导在伤口愈合中的重要性以及作为正常细胞转化为致瘤对应物的一个促成因素方面正证明具有极高价值。
