Bauer C, Bahnemann R
Institute of Parasitology, Justus Liebig University, Giessen, Germany.
Vet Parasitol. 1996 Oct 25;65(3-4):269-73. doi: 10.1016/s0304-4017(96)00976-4.
The efficacy of ivermectin against Filaroides hirthi was evaluated in a series of three trials using Beagle dogs of a breeding colony known to be endemically infected with this lungworm. Ivermectin was subcutaneously given at a dosage of 1 mg kg-1 bodyweight once to 40 (group A) or, at a one week interval, twice to 32 dogs (group B) 14-15 weeks prior to necropsy; another 40 dogs (group C) remained untreated. All animals were necropsied and lungs were digested using the pepsin-hydrochloride method and qualitatively examined for Filaroides spp. stages. A 44.8% and 74.1% reduction of the prevalence of lungworm infection as well as a 87.5% and 94.8% reduction of the proportion of dogs harbouring first-stage Filaroides spp. larvae were found in groups A and B, respectively, as compared to group C. These results suggest that repeated treatments of breeding dogs with ivermectin might reduce the transmission of F. hirthi infection to their offspring.
在一系列三项试验中，使用已知感染这种肺线虫的繁殖群体中的比格犬，评估了伊维菌素对赫氏丝状线虫的疗效。在尸检前14 - 15周，以1 mg kg-1体重的剂量对40只犬（A组）皮下注射伊维菌素一次，或对32只犬（B组）每隔一周皮下注射两次；另外40只犬（C组）不进行治疗。所有动物均进行尸检，并用胃蛋白酶 - 盐酸法消化肺脏，对丝状线虫各阶段进行定性检查。与C组相比，A组和B组肺线虫感染率分别降低了44.8%和74.1%，携带第一期丝状线虫幼虫的犬比例分别降低了87.5%和94.8%。这些结果表明，用伊维菌素反复治疗繁殖犬可能会减少赫氏丝状线虫感染向其后代的传播。
