Lee C G, Cho S H, Kim J T, Lee C Y
College of Veterinary Medicine, Chonnam National University, South Korea.
Vet Parasitol. 1996 Oct 25;65(3-4):307-11. doi: 10.1016/s0304-4017(96)00972-7.
Closantel (Flukiver), a salicylanilide antiparasitic compound, was tested in Korean native goats infected with Fasciola hepatica. The goats were administered closantel once orally at a dose of 10 mg/kg body weight. Efficacy was monitored weekly by fecal examination of all infected animals starting the second week post-treatment and continuing for 3 weeks. Closantel elicited 80.3, 97.8 and 92.7% efficacy in goats with naturally-acquired fasciolosis at the second, third and fourth week post-treatment, respectively. It elicited a 100% efficacy in goats experimentally infected with F. hepatica metacercariae and treated at 18 weeks post-infection.
