Korniushenko N P, Zriakov O M
Ukr Biokhim Zh. 1977 Jul-Aug;49(4):67-9.
Administration of estradiol-benzoate in a dose of 0.5 Mg for 4 days causes a twice increase in the content of acetylcholine in hypothalamus of impuberal female rats and statistically significant decrease in the content of GABA. The level of serotonin, dopamine, noradrenaline and histamine in the hypothalamus of the animals is not affected by 0.5 Mg of estradiol-benzoate. Administration of prolactin against a background of estradiol--benzoate normalizes the content of GABA and produces a statistically significantly drop in the level of acetylcholine in the hypothalamus. A conclusion is drawn that acetylcholine and GABA are involved into regulation of prolactin secretion in rats.
给未成熟雌性大鼠注射剂量为0.5毫克的苯甲酸雌二醇，持续4天，会使下丘脑乙酰胆碱含量增加两倍，GABA含量出现统计学上的显著下降。动物下丘脑的血清素、多巴胺、去甲肾上腺素和组胺水平不受0.5毫克苯甲酸雌二醇的影响。在苯甲酸雌二醇的基础上注射催乳素可使GABA含量正常化，并使下丘脑乙酰胆碱水平出现统计学上的显著下降。得出的结论是，乙酰胆碱和GABA参与大鼠催乳素分泌的调节。
