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[羧化反应刺激对失血性贫血家兔14CO2固定强度及人类贫血患者血液成分修复的影响]

[Effect of carboxylation reactions stimulation on intensity of 14CO2 fixation in rabbits with posthemorrhage anemia and on repairing of blood components in human anemia].

作者信息

Zhurbin G I, Gruzova L M, Mikhaĭlovs'ka L A, Stogniĭ N A, Guliĭ M F

出版信息

Ukr Biokhim Zh. 1977 Jul-Aug;49(4):74-9.

PMID:898321
Abstract

The repair processes with posthemorrhage anemia were studied in experiment and clinics as affected by the preparation (sodium bicarbonate and magnesium, manganese and zinc sulphates in a ratio of 25:5:0.1:0.1) which stimulates the carboxylation reactions in the organism. Stimulation of the carboxylation reactions in the rabbits with experimental posthemorrhage anemia increases the intensity of 14CO2 carbon transformation of organic compounds in the tricarboxylic cycle, intensifies 14C incorporation into the liver, kidneys, spleen and marrow proteins as well as into serum albumin and globulins. Under clinical conditions stimulation of CO2 fixation with the preparation favours an intensified formation of the red series cells and biosynthesis of hemoglobin and serum proteins as well as the repair of their disturbed balance in patients with posthemorrhage anemia. The content of magnesium in blood plasma normalizes.

摘要

在实验和临床中研究了出血后贫血的修复过程,该过程受一种制剂(碳酸氢钠与硫酸镁、硫酸锰和硫酸锌按25:5:0.1:0.1的比例混合)的影响,这种制剂能刺激机体中的羧化反应。对患有实验性出血后贫血的兔子进行羧化反应刺激,可提高三羧酸循环中有机化合物的14CO2碳转化强度,增强14C掺入肝脏、肾脏、脾脏和骨髓蛋白质以及血清白蛋白和球蛋白的能力。在临床条件下,用该制剂刺激CO2固定有利于出血后贫血患者红细胞的强化生成、血红蛋白和血清蛋白质的生物合成以及修复其失衡状态。血浆中的镁含量恢复正常。

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