Darbar D, Connachie A M, Jones A M, Newton R W
Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland.
Br J Clin Pract. 1996 Sep;50(6):350-1.
Carbamazepine is regularly used in the treatment of trigeminal neuralgia. Although exacerbation of psychosis has been described following abrupt discontinuation of carbamazepine in chronic schizophrenics, a withdrawal syndrome has not been reported previously in patients treated for trigeminal neuralgia. The case presented here suggests that abrupt withdrawal of toxic concentrations of carbamazepine may precipitate a withdrawal reaction, which is manifest some days after discontinuation of the drug. Therefore it may be advisable to withdraw therapy slowly in these situations.
卡马西平常用于治疗三叉神经痛。虽然已有报道称慢性精神分裂症患者突然停用卡马西平后会出现精神病症状加重的情况，但此前尚未有接受三叉神经痛治疗的患者出现戒断综合征的报道。本文所呈现的病例表明，突然停用中毒浓度的卡马西平可能会引发戒断反应，该反应在停药数天后显现。因此，在这些情况下缓慢停药可能是明智的。
