Kerem D
Israeli Naval Medical Institute, IDF Medical Corps, Haifa, Israel.
J Basic Clin Physiol Pharmacol. 1996;7(1):11-22. doi: 10.1515/jbcpp.1996.7.1.11.
The possibility of an altered susceptibility of the injured brain to central nervous system (CNS) oxygen toxicity was examined in awake rats. Moderate to severe closed head injury with diffuse axonal damage was produced in anesthetized rats by the fluid percussion method (2-2.5 atm), after which chronic EEG electrodes were implanted. Twenty-four hours later, the rats were exposed to 5 atm abs (506.5 kPa) oxygen and the time to appearance of paroxysmal EEG patterns was noted. The difference between the 19 minute median latency of this group and 16 minute of a control group which underwent a sham operation did not reach statistical significance. Some injured animals convulsed with minimal or no EEG changes. The clinical implication could be that brain injured patients are not at higher risk of CNS oxygen toxicity but the EEG alterations that could potentially be used to forecast incipient convulsions, or be the indication of actual convulsions in the intact brain of a paralyzed patient, may not always be present.
在清醒大鼠中研究了受伤大脑对中枢神经系统（CNS）氧中毒易感性改变的可能性。通过液压冲击法（2 - 2.5个大气压）在麻醉大鼠中造成中度至重度闭合性颅脑损伤并伴有弥漫性轴索损伤，之后植入慢性脑电图电极。24小时后，将大鼠暴露于5个绝对大气压（506.5千帕）的氧气中，并记录出现阵发性脑电图模式的时间。该组19分钟的中位潜伏期与接受假手术的对照组16分钟之间的差异未达到统计学显著性。一些受伤动物出现惊厥，但脑电图变化极小或无变化。临床意义可能是脑损伤患者发生中枢神经系统氧中毒的风险并不更高，但脑电图改变可能并不总是存在，而脑电图改变有可能用于预测初期惊厥，或作为瘫痪患者完整大脑中实际惊厥的指征。
