Sorokovoi V I, Nikitina G M, Mochenova N N
NII of Human Morphology RAMN, Moscow.
Vestn Ross Akad Med Nauk. 1996(9):35-40.
This study summarizes the experimental findings suggesting that plasmalemmal microvesicles formed from red blood cell aging are stimulators of erythropoiesis. The supposed sequence of events consists of microvesicular absorption by the settled macrophages of the liver and spleen, a message of information from circulatory monocytes (and lymphocytes) to the central macrophage of erythropoietic islands and regulation of late erythropoiesis. This is an autoerythronic regulation because it corrects red blood cell reproduction in relation to the rate of cell aging and thus differs from the classical humoral type which regulates erythrocytic reproduction according to visceral oxygen supply.
本研究总结了实验结果，表明由红细胞衰老形成的质膜微泡是红细胞生成的刺激物。推测的事件序列包括肝脏和脾脏中定居的巨噬细胞对微泡的吸收、循环单核细胞（和淋巴细胞）向红细胞生成岛中央巨噬细胞传递信息以及晚期红细胞生成的调节。这是一种自身红细胞生成调节，因为它根据细胞衰老速率校正红细胞的繁殖，因此不同于根据内脏氧供应调节红细胞繁殖的经典体液调节类型。
