Semenov S P, Kalashnikova E O, Oganesian G A
Morfologiia. 1996;109(3):14-8.
Celloidin slices of brain were studied histologically by means of Nissl method in Wistar line rats 3 and 8 months after kindling formation initiated by electrostimulation of the lateral hypothalamus emotiogenic zones. part of brain neurons appeared to acquire destructive changes, grow dark and wrinkle, while some of them died. A great number of such neurons were found in the nuclei of base brain, thalamus, hypothalamus and pons varolii with hemorrhages seen in different brain zones. Besides, 8 months after the kindling formation, large spherical bodies painted metachromatically by toluidin blue were found in white substance of many brain zones. These bodies are likely the product of generation and metabolic disorders in myelinated fibres. The data obtained indicate that kindling initiated by hyperexcitation of emotiogenic brain systems results in organic brain disease similar to that in epilepsy.
通过尼氏染色法对Wistar系大鼠脑组织火棉胶切片进行组织学研究。这些大鼠在通过电刺激下丘脑外侧情绪发生区引发点燃形成后的3个月和8个月。部分脑神经元似乎出现了破坏性变化，变得颜色加深且皱缩，其中一些死亡。在脑基底部、丘脑、下丘脑和脑桥核中发现大量此类神经元，不同脑区出现出血。此外，在点燃形成8个月后，在许多脑区的白质中发现了被甲苯胺蓝染成异染性的大球体。这些球体可能是有髓纤维生成和代谢紊乱的产物。所获得的数据表明，由情绪发生脑系统过度兴奋引发的点燃会导致类似于癫痫的器质性脑病。
