[Ultrastructural changes in the interstitial cells of the kidney medullary substance in suckling rabbits with experimental cholera].

A culture of virulent selection of cholera vibrios L-top 5879 was introduced through the probe to suckling rabbits-pups 10 to 12 days old. Ultrastructural changes of interstitial cells and capillaries of kidney medulla were studied. During vibrio adhesion (4 hrs after the inaction) interstitial cells acquire dystrophic changes, lipid granules content reduces, while vascular permeability grows higher which suggests the presence of prostaglandin precursors elimination into blood flow. Cholera development (1-2 days later) is accompanied with progressing of signs of prostaglandin synthesis activation and their precursors passage into the vascular bed.