Leont'eva G R, Zicha J, Kunes J
Morfologiia. 1996;110(4):105-8.
The action of chemical desympathization by 6-hydroxydophamine influencing adrenergic innervation in different organs vessels (mesenterial, renal and femoral) was studied using histochemical fluorescent method in salt susceptible and salt-resistant Dahl rats kept on a low- and high-salt diet. Heterogeneity of adrenergic innervation of different region vessels was established to display and 6-hydroxydophamine caused complete desympathization only in mesenterial artery and in all veins, while in renal artery retained adrenergic plexus its certain branching and femoral artery-in two thirds of its surface. The process of reinnervation in vessels running with different intensity in different animals and in different vessels was found to start in vessels of majority of animals on day 5-6 after the chemical desympathization. 6-hydroxydophamine had greater impact on the vessels of salt-susceptible high salt rat (hypertension) and salt-resistant high-salt-diet (normension) rats. Thus, the state of arterial and venous adrenergic apparatus in hypertension Dahl rats is determined not by the increased blood pressure itself but by the natrium metabolism disturbance.
采用组织化学荧光法，在高盐和低盐饮食饲养的盐敏感型和盐抵抗型Dahl大鼠中，研究了6 - 羟基多巴胺对不同器官血管（肠系膜血管、肾血管和股血管）肾上腺素能神经支配的化学去交感神经作用。不同区域血管的肾上腺素能神经支配存在异质性，6 - 羟基多巴胺仅使肠系膜动脉和所有静脉完全去交感神经化，而肾动脉保留了一定分支的肾上腺素能神经丛，股动脉在其表面的三分之二保留了肾上腺素能神经丛。发现在化学去交感神经作用后第5 - 6天，不同动物和不同血管中去神经支配程度不同的血管的再支配过程开始。6 - 羟基多巴胺对盐敏感型高盐大鼠（高血压）和盐抵抗型高盐饮食（血压正常）大鼠的血管影响更大。因此，高血压Dahl大鼠的动脉和静脉肾上腺素能装置的状态不是由血压升高本身决定的，而是由钠代谢紊乱决定的。
