Mizon P, Cossement C, Mannessier L, Caulier M T, Rose C, Goudemand J
Laboratoire d'Hématologie, Hôpital C. Huriez, Lille.
Transfus Clin Biol. 1996;3(4):257-61. doi: 10.1016/s1246-7820(96)80005-x.
Alloimmunization to red cell antigens and haemolytic transfusion reactions may occur after red blood cell transfusion. We describe a case of life threatening postransfusion hyperhaemolysis in a beta thalassaemia patient. For many years, transfusion therapy was stopped but the patient developed a profound anaemia which required splenectomy. At that time, the serum contained a red cell alloantibody with anti-KN3 specificity. In vivo red cell survival studies were performed trying to determine the capacity of this antibody to cause red cell destruction. Unfortunately, these studies triggered again an intense haemolytic process explained by the appearance of red cell auto- and alloantibodies. This case underlines a possible link between the development of alloimmunization and the induction of potentially serious autoimmune haemolytic anaemia.
红细胞输血后可能会发生针对红细胞抗原的同种免疫和溶血性输血反应。我们描述了一例β地中海贫血患者发生危及生命的输血后高溶血的病例。多年来，输血治疗停止，但患者出现严重贫血，需要进行脾切除术。当时，血清中含有一种具有抗KN3特异性的红细胞同种抗体。进行了体内红细胞存活研究，试图确定这种抗体导致红细胞破坏的能力。不幸的是，这些研究再次引发了强烈的溶血过程，这可以用红细胞自身抗体和同种抗体的出现来解释。该病例强调了同种免疫的发生与潜在严重自身免疫性溶血性贫血的诱导之间可能存在的联系。
