Newby D E, Neilson J M, Jarvie D R, Boon N A
Department of Cardiology, Royal Infirmary, Edinburgh.
Heart. 1996 Oct;76(4):355-7. doi: 10.1136/hrt.76.4.355.
To assess the role of caffeine restriction in the management of patients with symptomatic idiopathic ventricular premature beats.
A randomised, double blind, 6 week intervention trial incorporating dietary caffeine restriction, caffeinated coffee, and decaffeinated coffee.
Cardiac outpatient clinic.
13 patients with symptomatic frequent idiopathic ventricular premature beats.
Weekly measures of serum caffeine concentration, coffee consumption, visual analogue score of palpitations, and 24 hour ventricular premature beat frequency.
The interventions achieved significant alterations in serum caffeine concentrations (P < 0.001) which correlated with coffee consumption (r = 0.70; P < 0.001). Visual analogue palpitation scores showed a small, but significant correlation with ventricular premature beat frequencies (r = 0.34; P = 0.003). However, there were no significant changes in palpitation scores or ventricular premature beat frequencies during the intervention weeks and no significant correlations were found between these variables and serum caffeine concentrations.
Caffeine restriction has no role in the management of patients referred with symptomatic idiopathic ventricular premature beats.
评估限制咖啡因摄入在有症状的特发性室性早搏患者管理中的作用。
一项为期6周的随机双盲干预试验，包括饮食中限制咖啡因摄入、饮用含咖啡因咖啡和脱咖啡因咖啡。
心脏门诊。
13例有症状的频发特发性室性早搏患者。
每周测量血清咖啡因浓度、咖啡摄入量、心悸视觉模拟评分以及24小时室性早搏频率。
干预措施使血清咖啡因浓度发生了显著变化（P < 0.001），且与咖啡摄入量相关（r = 0.70；P < 0.001）。心悸视觉模拟评分与室性早搏频率呈小但显著的相关性（r = 0.34；P = 0.003）。然而，在干预期间，心悸评分或室性早搏频率没有显著变化，且这些变量与血清咖啡因浓度之间未发现显著相关性。
限制咖啡因摄入在有症状的特发性室性早搏转诊患者的管理中没有作用。
