Pavlov V, Dimitrov O
Mol Med (Sofia). 1996;1(2):16-21.
The important role of the natural polyamines putrescine, spermidine and spermine in the normal and pathological cell growth is the main reason for the active investigation of their metabolism. The essential catabolic reactions of polyamine interconversion and terminal oxidation as well as data for the catabolic enzymes and the regulatory mechanisms of their activities are reviewed. The importance of catabolic reactions for the maintenance of the optimal polyamine concentrations during the cell growth and differentiation is also presented. The role of the essential catabolic enzymes spermidine/spermine N1-acetyltransferase, polyamine oxidase and diamine oxidase in normal and pathological cell growth is discussed.
天然多胺腐胺、亚精胺和精胺在正常及病理细胞生长中的重要作用是对其代谢进行积极研究的主要原因。本文综述了多胺相互转化和末端氧化的关键分解代谢反应，以及分解代谢酶的数据及其活性调节机制。还介绍了分解代谢反应对于在细胞生长和分化过程中维持最佳多胺浓度的重要性。讨论了关键分解代谢酶亚精胺/精胺N1-乙酰基转移酶、多胺氧化酶和二胺氧化酶在正常及病理细胞生长中的作用。
