Hedrick J L
Section of Molecular and Cellular Biology, University of California, Davis 95616, USA.
J Reprod Fertil Suppl. 1996;50:9-17.
For rational and optimal use of the zona pellucida glycoproteins as antigens for immunocontraception, a comprehensive understanding of their structure, function and antigenic properties is necessary. The antigenic relatedness of the pig zona pellucida glycoproteins were analysed and compared with three glycoproteins cloned from ovarian cDNA libraries of the anuran Xenopus laevis. The vitelline envelope from Xenopus laevis eggs (an extracellular matrix structure equivalent to the mammalian zona pellucida) is composed of glycoproteins that are homologous to the three mammalian zona pellucida glycoproteins, ZPA, ZPB and ZPC. The experimental results were used to make antigenic and functional (fertilization) predictions about zona pellucida glycoproteins. These studies provide a potentially useful perspective for devising immunocontraceptive methods of fertility regulation.
为了合理且最优地利用透明带糖蛋白作为免疫避孕的抗原，有必要全面了解它们的结构、功能和抗原特性。分析了猪透明带糖蛋白的抗原相关性，并与从无尾两栖动物非洲爪蟾卵巢cDNA文库中克隆的三种糖蛋白进行了比较。非洲爪蟾卵的卵黄膜（一种相当于哺乳动物透明带的细胞外基质结构）由与三种哺乳动物透明带糖蛋白ZPA、ZPB和ZPC同源的糖蛋白组成。实验结果被用于对透明带糖蛋白进行抗原性和功能性（受精方面）预测。这些研究为设计生育调节的免疫避孕方法提供了一个潜在有用的视角。
