Schilling A, Hofstetter A, Marx F J
Urologe A. 1977 Jul;16(4):238-40.
Failure of microcirculation in septic shock is due to the generalized release of catecholamins following a fall in cardiac output by the activity of bacterial toxin. The failure of the microcirculation can be defined as 1. a failure of the distribution of the tissue perfusion, and 2. a decrease of capillary flow due to obstructed inflow, reduced capillary flow passage and obstructed outflow. Bloodviscosity increases because of fluid sequestration, aggregation of rbc's and decrease in velocity of the blood flow. All this results in a dispariaty of oxygen consumption and availability to the tissue. The characteristics of specific organ disturbances in shock go along with the distribution of the alpha-receptors in each organ, the specific physiological function and architecture of the organ as well as previous diseases of the organ.
脓毒性休克时微循环衰竭是由于细菌毒素作用导致心输出量下降后儿茶酚胺大量释放所致。微循环衰竭可定义为：1. 组织灌注分布失败；2. 由于流入受阻、毛细血管血流通道减少和流出受阻导致毛细血管血流减少。由于液体隔离、红细胞聚集和血流速度降低，血液粘度增加。所有这些都导致组织氧消耗和氧供应的差异。休克中特定器官功能障碍的特征与每个器官中α受体的分布、器官的特定生理功能和结构以及器官既往疾病有关。
