Kosogorova L S, Kovalenko N N, Liubenko V A, Novosad F I
Institute of Phthisiology and Pulmonology of FG Ianovskogo, Ukraine AMN, Kiev.
Probl Tuberk. 1996(5):41-4.
It has been found that among patients with bronchial asthma (BA) there are individuals with primary complete or partial lymphocytic resistance to glucocorticoid hormones (GC), which is apparently to be associated with cellular immunodeficiency and lower counts of young cortisol-sensitive cells in these patients. This condition may be aggravated with GC use and may appear as steroid dependence with all its clinical manifestations. It has been demonstrated that cellular steroid dependence may be either decreased or completely eliminated by special therapy aimed at enhancing lymphocytic sensitivity to hormones. Nicotinamide served as the drug of choice, which promoted the recovery of GC lymphocytic sensitivity, which may be attributed to the positive effects of the drug on the systemic immunity of BA patients.
已经发现，在支气管哮喘（BA）患者中，有一部分个体对糖皮质激素（GC）存在原发性完全或部分淋巴细胞抵抗，这显然与细胞免疫缺陷以及这些患者中年轻的皮质醇敏感细胞数量减少有关。这种情况可能会因使用GC而加重，并可能表现为具有所有临床表现的类固醇依赖。已经证明，通过旨在增强淋巴细胞对激素敏感性的特殊疗法，细胞类固醇依赖可能会降低或完全消除。烟酰胺是首选药物，它促进了GC淋巴细胞敏感性的恢复，这可能归因于该药物对BA患者全身免疫的积极作用。
