Jaracz J, Rajewski A, Junik R, Sowiński J, Gembicki M
Kliniki Psychiatrii Dorosłych AM im. K. Marcinkowskiego w Poznaniu.
Psychiatr Pol. 1996 Sep-Oct;30(5):757-69.
Twenty patients who met the DSM-IV criteria for major depressive disorder were investigated at rest using Single Photon Emission Computed Tomography (SPECT). Participation in the study required a minimum score of 18 points on the 17-item Hamilton Rating Scale. All patients were drug free for at least one week before the SPECT scan. Assessments were made twice during depression and after recovery. Regional tracer uptake was measured by a semiquantitative method. The reference region was delineated on the cerebellum. In remission a significant increase of 99m Tc-uptake in almost all regions of interest was observed what may point on the improvement of regional blood flow after recovery from depression. For most regions except right frontal and left parietooccipital there were no significant differences of tracer uptake between patients with bipolar and unipolar depression. The negative correlation between regional cerebral blood flow and Hamilton score was found in temporal areas and left temporo-parietal region. We did not find the influence of age on regional cerebral blood flow. In conclusion, during depression global reduction of brain metabolism was observed, which may point on the role of subcortical nuclei with diffuse cortical projection in pathogenesis of depression.
对20名符合《精神疾病诊断与统计手册》第四版（DSM-IV）中重度抑郁症标准的患者在静息状态下使用单光子发射计算机断层扫描（SPECT）进行了研究。参与研究要求在17项汉密尔顿评定量表上的得分至少为18分。所有患者在SPECT扫描前至少一周未服用药物。在抑郁期间和康复后进行了两次评估。通过半定量方法测量局部示踪剂摄取。参考区域划定在小脑。在缓解期，观察到几乎所有感兴趣区域的99m锝摄取显著增加，这可能表明从抑郁症恢复后局部血流有所改善。对于除右额叶和左顶枕叶外的大多数区域，双相抑郁症患者和单相抑郁症患者之间的示踪剂摄取没有显著差异。在颞叶区域和左颞顶叶区域发现局部脑血流量与汉密尔顿评分之间呈负相关。我们没有发现年龄对局部脑血流量的影响。总之，在抑郁期间观察到大脑代谢整体降低，这可能表明具有弥散性皮质投射的皮质下核团在抑郁症发病机制中的作用。
