Blum H E
Abteilung Innere Medizin II, Medizinische Universitätsklinik Freiburg.
Praxis (Bern 1994). 1996 Nov 19;85(47):1502-6.
The structure and genetic organization of the hepatitis viruses A-E are well characterized. HAV and HEV cause acute and sometimes fulminant hepatitis. By contrast, HBV, HCV and HDV infections frequently progress to chronic hepatitis, liver cirrhosis and hepatocellular carcinoma (HCC). The specific detection of the hepatitis viruses A-E is based on serological and molecular analyses. In clinical practice, it is possible in most cases to identify the viral infection by a single serological screening test. In particular clinical situations, the diagnostic workup requires additional serological or molecular analyses. Given the different diagnostic tests, it is possible today to specifically identify the etiologic agent in most patients with acute or chronic viral hepatitis.
甲型至戊型肝炎病毒的结构和基因组织已得到充分表征。甲型肝炎病毒(HAV)和戊型肝炎病毒(HEV)可引起急性肝炎,有时还会导致暴发性肝炎。相比之下,乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)和丁型肝炎病毒(HDV)感染常常会发展为慢性肝炎、肝硬化和肝细胞癌(HCC)。甲型至戊型肝炎病毒的特异性检测基于血清学和分子分析。在临床实践中,大多数情况下通过单一血清学筛查试验就有可能识别病毒感染。在特定临床情况下,诊断检查需要进行额外的血清学或分子分析。鉴于有不同的诊断检测方法,如今在大多数急性或慢性病毒性肝炎患者中能够特异性地识别病原体。