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[对乙酰氨基酚中毒的治疗建议。丹麦医学协会,肝脏研究]

[Recommendations for treatment of paracetamol poisoning. Danish Medical Society, Study of the Liver].

作者信息

Clemmesen J O, Ott P, Dalhoff K P, Astrup L B, Tage-Jensen U, Poulsen H E

机构信息

Medicinsk afdeling A-2101, Rigshospitalet, København.

出版信息

Ugeskr Laeger. 1996 Nov 25;158(48):6892-5.

PMID:8984750
Abstract

Based on recent reports concerning the efficacy of N-acetylcysteine (NAC) in paracetamol (acetaminophen) poisoning, guidelines for treatment and control of these patients are reviewed by a study group under the Danish Association for the Study of the Liver. It is recommended that NAC-treatment is initiated immediately after referral and continued for 36 hours in all cases. Further NAC-treatment should not be discontinued before a decrease in INR has been observed.

摘要

基于近期有关N-乙酰半胱氨酸(NAC)对扑热息痛(对乙酰氨基酚)中毒疗效的报告,丹麦肝脏研究协会下属的一个研究小组对这些患者的治疗和控制指南进行了审查。建议在转诊后立即开始NAC治疗,并在所有病例中持续36小时。在观察到国际标准化比值(INR)下降之前,不应停止进一步的NAC治疗。

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Ugeskr Laeger. 1996 Nov 25;158(48):6892-5.
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引用本文的文献

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A review of the evidence concerning hepatic glutathione depletion and susceptibility to hepatotoxicity after paracetamol overdose.对乙酰氨基酚过量服用后肝脏谷胱甘肽耗竭与肝毒性易感性相关证据的综述。
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Does cytochrome P450 liver isoenzyme induction increase the risk of liver toxicity after paracetamol overdose?
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N-acetylcysteine overdose after acetaminophen poisoning.对乙酰氨基酚中毒后N-乙酰半胱氨酸过量
Int Med Case Rep J. 2015 Feb 27;8:65-9. doi: 10.2147/IMCRJ.S74563. eCollection 2015.
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Age and paracetamol self-poisoning.年龄与对乙酰氨基酚自我中毒
Gut. 2005 May;54(5):686-90. doi: 10.1136/gut.2004.054619.
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Hospital discharges and 30-day case fatality for drug poisoning: a Danish population-based study from 1979 to 2002 with special emphasis on paracetamol.药物中毒的医院出院情况及30天病死率:一项基于丹麦人群的1979年至2002年研究,特别关注对乙酰氨基酚。
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