Límanová Z, Barkmanová J, Friedmannová Z, Kasparová E, Tichá E, Spanlangová I, Jelínková A
III. interní klinika VFN, Praha.
Vnitr Lek. 1996 Sep;42(9):605-9.
Data in the literature concerning thyroid disease in women after treatment of breast cancer differ. The authors examined therefore the thyroid function (thyroid stimulating hormone, thyroxine, triiodothyronine, antibodies against thyroid peroxidase and against thyroglobulin) in a random sample of 76 women after ablation of the breast on account of carcinoma. A deviation in some of the investigated indicators was found in 46,7% of the examined women. A total of 10,5% women had an elevated level of thyroid stimulating hormone, in 18,4% both antibodies were positive, in another 11,8% antibodies against thyroglobulin only were positive and in 9,2% antibodies against thyroid peroxidase were positive. In none of the women the thyroxine level was beyond the physiological, i.e. normal range, the triiodothyronine level was elevated in 5,2%. Newly diagnosed subclinical hypothyroidism in 10,5% of the group supports the hypothesis of a more frequent thyroid abnormality in women treated on account of breast cancer. The cause and sequelae of this finding will be investigated.
关于乳腺癌治疗后女性甲状腺疾病的文献数据存在差异。因此，作者对76名因癌症行乳房切除术后的女性进行了随机抽样，检测其甲状腺功能（促甲状腺激素、甲状腺素、三碘甲状腺原氨酸、抗甲状腺过氧化物酶抗体和抗甲状腺球蛋白抗体）。在46.7%的受检女性中发现某些被调查指标存在偏差。共有10.5%的女性促甲状腺激素水平升高，18.4%的女性两种抗体呈阳性，另有11.8%的女性仅抗甲状腺球蛋白抗体呈阳性，9.2%的女性抗甲状腺过氧化物酶抗体呈阳性。所有女性的甲状腺素水平均未超出生理范围，即正常范围，三碘甲状腺原氨酸水平升高的占5.2%。该组中10.5%的女性新诊断为亚临床甲状腺功能减退，这支持了乳腺癌治疗女性中甲状腺异常更为常见的假说。将对这一发现的原因和后果进行调查。
