Pletsityĭ K D, Davydova T V, Fomina V G, Nikushkin E V, Kucherianu V G, Iurasov V V
Vopr Pitan. 1996(4):11-3.
It was shown in experiments on mice that 1.25 (OH)2D3 ingested per os in dose 100 ng during 5 days caused the great increasing of lipid peroxidation (LP) in peritoneal macrophages and spleen cells. The evidence of LP induction is the production of TBA-positive substances in these cells. Linear negative dependence was found between increasing of LP and functional activity of lymphocytes which was evidenced by blast transformation of lymphocytes under effect of concanavalin or mitogen of laconose. Linear positive correlation was shown between level of LP and function of macrophages.
在对小鼠的实验中发现，连续5天口服剂量为100纳克的1,25（OH）₂D₃会导致腹膜巨噬细胞和脾细胞中脂质过氧化（LP）大幅增加。LP诱导的证据是这些细胞中产生TBA阳性物质。在LP增加与淋巴细胞功能活性之间发现了线性负相关，这通过伴刀豆球蛋白或乳糖促细胞分裂剂作用下淋巴细胞的母细胞转化得到证明。LP水平与巨噬细胞功能之间呈现线性正相关。
