Kim S Y, Cho M H
Department of Anaesthesiology, Soon Chun Hyang University and Hospital, Seoul, Korea.
Anaesthesia. 1996 Oct;51(10):929-31. doi: 10.1111/j.1365-2044.1996.tb14959.x.
We investigated isobolic mixtures of mivacurium and rocuronium to determine if the combination offered any advantages over either drug alone. We used five dose regimens to achieve ED95 x 2: [(1.5 x ED95 mivacurium) + (0.5 x ED95 rocuronium); (1 x ED95 mivacurium) + (1 x ED95 rocuronium); (0.5 x ED95 mivacurium) + (1.5 x ED95 rocuronium); (2 x ED95 mivacurium); (2 x ED95 rocuronium)]. We studied onset time, duration of block, recovery of block, arterial blood pressure and heart rate. Mivacurium alone produced the block of shortest duration (p < 0.001). Onset time was shortest in the rocuronium alone group and was significantly faster in all the rocuronium treated groups compared to mivacurium alone (p < 0.001). Arterial blood pressure and heart rate decreased transiently in the mivacurium alone group but not in the other groups. These results demonstrate increased cardiovascular stability and more rapid onset of block with combinations of mivacurium and rocuronium without significant prolongation of the block.
我们研究了米库氯铵和罗库溴铵的等效剂量混合物，以确定该组合是否比单独使用任何一种药物具有优势。我们采用五种剂量方案来达到ED95×2：[(1.5×ED95米库氯铵)+(0.5×ED95罗库溴铵);(1×ED95米库氯铵)+(1×ED95罗库溴铵);(0.5×ED95米库氯铵)+(1.5×ED95罗库溴铵);(2×ED95米库氯铵);(2×ED95罗库溴铵)]。我们研究了起效时间、阻滞持续时间、阻滞恢复情况、动脉血压和心率。单独使用米库氯铵产生的阻滞持续时间最短（p<0.001）。单独使用罗库溴铵组的起效时间最短，与单独使用米库氯铵相比，所有罗库溴铵治疗组的起效时间明显更快（p<0.001）。单独使用米库氯铵组的动脉血压和心率短暂下降，而其他组则没有。这些结果表明，米库氯铵和罗库溴铵联合使用可提高心血管稳定性，使阻滞起效更快，且阻滞时间无明显延长。
