通过区域选择性转糖基化完全合成3'-唾液酸-N-乙酰乳糖胺
Complete synthesis of 3'-sialyl-N-acetyllactosamine by regioselective transglycosylation.
作者信息
Vetere A, Paoletti S
机构信息
Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Università degli Studi di Trieste, Italy.
出版信息
FEBS Lett. 1996 Dec 16;399(3):203-6. doi: 10.1016/s0014-5793(96)01267-7.
PMID:8985145
Abstract
Transglycolytic synthesis of 3'-sialyl-N-acetyllactosamine by sequential use of beta-galactosidase from Bacillus circulans and trans-sialidase from Trypanosoma cruzi was described. These reactions depicted the first complete synthesis of a biologically important oligosaccharide with high regioselectivity avoiding use of glycosyltransferases and NDP sugars.
摘要
描述了通过依次使用环状芽孢杆菌的β-半乳糖苷酶和克氏锥虫的转唾液酸酶进行转糖基合成3'-唾液酸-N-乙酰乳糖胺的过程。这些反应首次以高区域选择性完全合成了一种具有生物学重要性的寡糖，避免了使用糖基转移酶和核苷二磷酸糖。
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