Kitazawa Y, Yamamoto T, Sawada A, Hagiwara Y
Department of Ophthalmology, Gifu University School of Medicine, Japan.
Aust N Z J Ophthalmol. 1996 Nov;24(4):327-32. doi: 10.1111/j.1442-9071.1996.tb01603.x.
To determine the surgical outcome of mitomycin trabeculectomy in patients with refractory glaucoma.
Sixty-six eyes of 52 patients with refractory glaucoma underwent mitomycin trabeculectomy. Mitomycin was applied for five minutes only once during trabeculectomy. The follow-up period was six to 61 months.
Cumulative success probability was calculated using Kaplan-Meier life-table analysis assuming the cut-off postoperative IOP to be 20 mmHg or IOP reduction by at least 20% in eyes with preoperative IOP 24 mmHg. At the end of 61-month follow-up the success probability was 80% +/- 6% without postoperative ocular hypotensive medication (complete success) and was 95% +/- 3% regardless of postoperative antiglaucoma medication (overall success), respectively.
The data suggest that mitomycin trabeculectomy is efficacious in reducing IOP in patients with refractory glaucoma.
确定丝裂霉素小梁切除术治疗难治性青光眼的手术效果。
52例难治性青光眼患者的66只眼接受了丝裂霉素小梁切除术。丝裂霉素仅在小梁切除术中应用一次，持续5分钟。随访时间为6至61个月。
采用Kaplan-Meier生存表分析计算累积成功概率，假设术后眼压临界值为20 mmHg，或术前眼压≥24 mmHg的患者眼压降低至少20%。在61个月随访结束时，未使用术后降眼压药物时的成功概率为80%±6%（完全成功），无论术后是否使用抗青光眼药物时的成功概率为95%±3%（总体成功）。
数据表明丝裂霉素小梁切除术在降低难治性青光眼患者眼压方面有效。
