Fletcher L M
Liver Unit, Queensland Institute of Medical Research/University of Queensland Joint Liver Programme, Herston, Australia.
J Gastroenterol Hepatol. 1996 Nov;11(11):1039-41. doi: 10.1111/j.1440-1746.1996.tb00032.x.
The consumption of excessive amounts of alcohol affects human iron homeostasis and an association of iron overload and heavy alcohol consumption has been recognized for many years. Both major proteins of iron metabolism, ferritin and transferrin, are affected by alcohol. Increased hepatic iron levels are seen in a high proportion of alcoholic subjects, sometimes causing confusion in diagnosis between alcoholic liver disease and iron-overload disease. The pattern of deposition of this iron in alcoholics, however, differs from that seen in the iron-overload disease haemochromatosis. Excessive alcohol consumption causes transferrin to become carbohydrate deficient, which allows it to be used as an efficient biochemical marker of alcohol abuse. It is concluded that alcohol consumption in moderation is unlikely to have deleterious health consequences.
过量饮酒会影响人体铁稳态，铁过载与大量饮酒之间的关联已被认识多年。铁代谢的两种主要蛋白质，即铁蛋白和转铁蛋白，都会受到酒精的影响。在很大比例的酒精性肝病患者中可见肝脏铁水平升高，这有时会导致酒精性肝病和铁过载疾病诊断上的混淆。然而，酒精性肝病患者体内铁的沉积模式与铁过载疾病血色素沉着症不同。过量饮酒会导致转铁蛋白缺乏碳水化合物，这使其能够作为酒精滥用的有效生化标志物。结论是适度饮酒不太可能对健康产生有害影响。
