Sundick R S, Bagchi N, Brown T R
Department of Immunology/and Microbiology, Wayne State University, Detroit, MI, USA.
Exp Clin Endocrinol Diabetes. 1996;104 Suppl 3:4-6. doi: 10.1055/s-0029-1211668.
The OS and the related Cornell C strain are interesting animal models for the study of the etiology of autoimmune thyroiditis. They are especially valuable for studying the etiologic role of thyroid abnormalities and abnormalities in the processing of iodine. Limitations of the model are the scarcity of immunological reagents for chickens, the absence of avian cloned thyroid-specific genes, minimal amounts of microsomal antibody and some differences between OS chickens and Hashimoto's patients in the types of thyroid abnormalities observed.
OS鸡和相关的康奈尔C品系是用于研究自身免疫性甲状腺炎病因的有趣动物模型。它们对于研究甲状腺异常和碘代谢异常的病因学作用特别有价值。该模型的局限性在于鸡的免疫试剂稀缺、缺乏禽类克隆的甲状腺特异性基因、微粒体抗体量极少，以及在观察到的甲状腺异常类型方面，OS鸡与桥本氏病患者之间存在一些差异。
